Aequus Advances Clinical Development of Transdermal Aripiprazole Patch

Oct 17, 2016

Vancouver, BC. October 17, 2016 – Aequus Pharmaceuticals Inc. (TSX-V: AQS, OTCQB: AQSZF) (“Aequus” or the “Company”), a specialty pharmaceutical company with a focus on developing, advancing and promoting differentiated products, announced today that is has filed a Clinical Trial Application (CTA) with Health Canada for its once-weekly transdermal aripiprazole patch. Aequus has developed this product to provide patients with sustained and controlled delivery of aripiprazole in a convenient, weekly dosage form. Upon approval of the CTA, the Company plans to initiate a repeat dose, 28-day safety and bioavailability study of aripiprazole transdermal patches in eight healthy volunteers in late 2016.

Aripiprazole is an atypical antipsychotic and the active ingredient in Abilify ®, a leading medication in the US used for the treatment of a number of psychiatric disorders including bipolar I disorder, schizophrenia, major depressive disorder and irritability associated with autistic disorder. Patient adherence to antipsychotic medication is a significant challenge, and presents an estimated 42% risk of relapsing following a missed dose. A seven-day application of aripiprazole is intended to provide patients with a convenient and easy to use long acting alternative and is expected to reduce the rate of relapse that may result from patients not adhering to their prescribed dosing schedule.

The currently planned study is a follow-on to the successfully completed single exposure proof of concept study, which suggested that the current formulation delivers sustained levels of therapeutic doses of aripiprazole over a seven day period. The planned repeat dose proof of concept study has a primary objective to assess the bioavailability of aripiprazole delivered in patch form after repeated administration in healthy volunteers. The secondary objective of the study is to assess the safety and tolerability of aripiprazole transdermal patch following repeated administration over a period of 4 weeks.

“We are very excited to see the continued advancement of this program,” said Dr. Don McAfee, Chief Scientific Officer at Aequus. “A seven-day patch that reliably delivers a sustained dose of aripiprazole has the potential to improve treatment adherence, reducing the risk of relapse associated with missed doses and reducing the burden of medicating in both home care settings and in institutions.”


Aequus Pharmaceuticals Inc. (TSX-V: AQS, OTCQB: AQSZF) is a growing specialty pharmaceutical company focused on developing and commercializing high quality, differentiated products. Aequus’ development stage pipeline includes several products in neurology and psychiatry with a goal of addressing the need for improved medication adherence through enhanced delivery systems. Aequus intends to commercialize its internal programs in Canada alongside its current portfolio of marketed established medicines and will look to form strategic partnerships that would maximize the reach of its product candidates worldwide. Aequus plans to build on its Canadian commercial platform through the launch of additional products that are either created internally or brought in through an acquisition or license; remaining focused on highly specialized therapeutic areas. For more information please visit

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