Aequus Announces Positive Skin Irritation Results for Once-Weekly Transdermal Aripiprazole

May 28, 2015

Vancouver, BC - May 28, 2015 - Aequus Pharmaceuticals, Inc., “Aequus” (TSX-V: AQS), announced today they have received positive skin irritation results in animal studies for their lead program, AQS-1301, a once-weekly transdermal formulation of aripiprazole. The formulation will be advanced into a comprehensive animal pharmacokinetic study in June which is expected to confirm that the transdermal patch is delivering target levels of drug. The results from these studies will then inform the Proof of Concept clinical trial in humans which is expected in the second half of 2015.

“We are very encouraged by the progress being made on AQS-1301,” said Dr. Don McAfee, Chief Scientific Officer of Aequus. “These skin irritation studies give us confidence that we are on the right track to manufacture a skin patch that will safely deliver sufficient amount of drug to treat patients with psychiatric disorders.”

The oral, once-daily formulation of aripiprazole is currently marketed under the trade name Abilify, which is an atypical antipsychotic, used for the treatment of bipolar I disorder, schizophrenia, irritability associated with autistic disorder, and major depressive disorder. Abilify is a market leader in the U.S., and Aequus believes it has limitations due to its daily dosing regimen which is associated with frequent missed doses and subsequent risk of relapse. Aequus’ proposed transdermal, once-weekly aripiprazole patch is designed to deliver aripiprazole consistently over a seven-day period at levels equivalent to currently marketed once-daily formulations. By delivering aripiprazole over seven days in a comfortable, convenient, easy-to-monitor and easy-to-use weekly patch, AQS-1301 is intended to promote enhanced medication adherence.


Aequus Pharmaceuticals Inc. is a Vancouver-based specialty pharmaceutical company focused on enhancing delivery methods for approved drugs that are limited by non-compliance, high frequency dosing, first-pass metabolism side-effects, painful injections, or where the therapeutic profile can be improved by making a long-acting alternative available. Aequus’ early-stage pipeline is focused on neurology and psychiatry products where there is a high medical need for an alternate route of delivery. Aequus’ lead-program, AQS-1301, is a once-weekly transdermal formulation of aripiprazole in development for the potential treatment of irritability associated with autistic disorder, bipolar disorder, schizophrenia, and major depressive disorder. AQS-1301 is currently in pre-clinical development and will be entering Proof of Concept clinical studies in the second half of 2015. For further information, please visit

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